A COMPARATIVE STUDY BETWEEN DESFLURANE AND SEVOFLURANE INHALATIONAL ANESTHESIA IN ROCURONIUM CONSUMPTION DURING GENERAL ANESTHESIA WITH FENTANYL AND REMIFENTANIL
DOI:
https://doi.org/10.55302/vq01e571Keywords:
desflurane, sevoflurane, remifentanil, fentanil, rocuroniumAbstract
Introduction: Rocuronium is a non-depolarizing neuromuscular blocking agent commonly used in anesthesia for muscle relaxation during surgery. It is frequently administered in combination with inhalational anesthetics like sevoflurane or desflurane, as well as opioids like fentanyl or remifentanil. They have distinct pharmacodynamic effects that can alter the required dose of rocuronium to achieve optimal muscle relaxation.
Objectives: The purpose of this study is to compare the consumption of rocuronium in four common anesthetic combinations: desflurane with remifentanil, desflurane with fentanyl, sevoflurane with remifentanil and sevoflurane with fentanyl.
Material and methods: This study included ASA I and II patients undergoing surgery who were randomly assigned into four groups. We used standard hemodynamic monitoring, the Train of Four (TOF) and the Bispectral Index System (BIS) to determine the depth of the anesthesia. We recorded the consumption of neuromuscular relaxant rocuronium in milligrams from intubation until weaking of the patient.
Results: The results obtained in both patient groups demonstrate a significantly lower consumption of rocuronium in the patients who received a desflurane inhalation anesthetic with remifentanil compared to the patients who received a sevoflurane inhalation anesthetic with fentanyl. This is thought to be due to the faster pharmacokinetic profile of desflurane, leading to an accelerated elimination in the patients, in combination with remifentanil, a short-acting opioid. Conclusion: This study contributed to an awareness of the differences in impact between the two inhalation anesthetics in the consumption of muscle relaxants for general anesthesia.
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