ANESTHESIA MANAGEMENT IN A PATIENT WITH ROCURONIUM ALLERGY

Authors

  • Sanja Kolevska City General Hospital “8th of September”, Skopje, Republic of North Macedonia Author

DOI:

https://doi.org/10.67214/pzrqwg35

Keywords:

avoiding muscle relaxants, general anesthesia, neuromuscular blocking agent free anesthesia, rocuronium allergy

Abstract

Neuromuscular blocking agents (NMBAs) are commonly used in anesthesia but are also leading causes of perioperative anaphylaxis, posing a significant challenge for anesthesiologists. This case report describes the anesthetic management of a 63-years-old male with a document- ed allergy to rocuronium undergoing femoro-femoral crossover bypass surgery. Despite nega- tive allergy testing prior to surgery, the procedure was conducted without the use of NMBAs to avoid potential anaphylaxis. Induction and maintenance of the anesthesia were achieved with propofol and remifentanil, ensuring excellent intubation conditions and hemodynamic stability throughout the whole surgery. The patient had an uneventful recovery and was discharged on the third postoperative day. This report highlights the feasibility and safety of an NMBA-free anesthetic approach, particularly for patients with contraindications. It underscores the impor- tance of individualized anesthetic planning and the effective use of alternative techniques to ensure patient’s safety and optimal surgical outcomes.

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References

1. Cook D, Simons DJ. Neuromuscular Blockade. [Updated 2023 Nov 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan; PMID: 30855885.

2. Peroni DG, Sansotta N, Bernardini R, et al. Muscle relaxants allergy. Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3 Suppl): S35-46. doi:10.1177/03946320110240s306. PMID: 22014924.

3. Paul Michel Mertes, Gerald W. Volcheck: Anaphylaxis to Neuromuscular-blocking Drugs: All Neuromuscular-blocking Drugs Are Not the Same. Anesthesiology 2015; 122:5–7 doi:10.1097/ALN.0000000000000516.

4. Mertes PM, Aimone-Gastin I, Guéant-Rodriguez RM, et al. Hypersensitivity reactions to neuromuscular blocking agents. Curr Pharm Des. 2008;14(27):2809-25; doi:10.2174/138161208786369704. PMID: 18991700.

5. Li J, Best OG, Rose MA, Green SL, Fulton RB, Capon MJ, Krupowicz BA, Fernando SL. Assessing cross-reactivity to neuromuscular blocking agents by skin and basophil activation tests in patients with neuromuscular blocking agent anaphylaxis. Br J Anaesth. 2019 Jul;123(1): e144-e150; doi: 10.1016/j.bja.2019.03.001. Epub 2019 Apr 5. PMID: 30961915.

6. Stephan R. Thilen, Wade A. Weigel, Michael M. Todd, et al. 2023 American Society of Anesthesiologists Practice Guidelines for Monitoring and Antagonism of Neuromuscular Blockade: A Report by the American Society of Anesthesiologists Task Force on Neuromuscular Blockade. Anesthesiology 2023; 138:13–41 doi:10.1097/ALN.0000000000004379.

7. C. Baillard, A.M. Korinek, V. Galanton1 et al. Anaphylaxis to rocuronium, BJA: British Journal of Anaesthesia, Volume 88, Issue 4, 1 April 2002, Pages 600–602, doi:10.1093/bja/88.4.600.

8. A. W. Woods, S. Allam, Tracheal intubation without the use of neuromuscular blocking agents, BJA: British Journal of Anaesthesia, Volume 94, Issue 2, February 2005, Pages 150–158, https://doi.org/10.1093/bja/aei006.

9. Striebel HW, Hölzl M, Rieger A, et al. Endotracheale Intubation unter Propofol und Fentanyl [Endotracheal intubation with propofol and fentanyl]. Anaesthesist. 1995 Dec;44(12):809-17. German. doi: 10.1007/s001010050216. PMID: 8594954.

10. Erkan Soylu, Burak Kersin, Pelin Karaaslan, et al. Effect of anesthesia without a neuromuscular blocking agent on intraoperative bleeding in adenotonsillectomy patients, International Journal of Pediatric Otorhinolaryngology, Volume 79, Issue 6, 2015, Pages 909-911, ISSN 0165-5876, doi: 10.1016/j.ijporl.2015.04.007.

11. Arora D, Prakash S, Bhartiya V et al. A combination of fentanyl-midazolam-propofol provides better intubating conditions than fentanyl-lignocaine-propofol in the absence of neuromuscular blocking agents. Acta Anaesthesiol Scand. 2006 Sep;50(8):999-1004. doi:10.1111/j.1399-6576.2006.01093.x. PMID: 16923097.

12. Jiung Jeong, Jeong-Eun Yun, Hyun Jee Kim, et al. Neuromuscular blocking agent re-exposure in a retrospective cohort with neuromuscular blocking agent–associated anaphylaxis, Annals of Allergy, Asthma & Immunology, Volume 131, Issue 5, 2023, Pages 637-644.e1, ISSN 1081-1206, doi: 10.1016/j.anai.2023.06.023.

13. Jeffrey I. Reddy, Peter J. Cooke, Johan M. van Schalkwyk, et al. Anaphylaxis Is More Common with Rocuronium and Succinylcholine than with Atracurium. Anesthesiology 2015; 122:39–45, doi:10.1097/ALN.0000000000000512.

14. Rodney G, Raju P, Belford I. Should neuromuscular blocking agents always be used? Response to Br J Anaesth 2018; 120: 1150-3. Br J Anaesth. 2019 Jan;122(1): e8-e9. doi: 10.1016/j.bja.2018.09.013. Epub 2018 Oct 25. PMID: 30579422.

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Published

09-12-2024

How to Cite

ANESTHESIA MANAGEMENT IN A PATIENT WITH ROCURONIUM ALLERGY. (2024). Macedonian Journal of Anaesthesia, 8(4), 136-141. https://doi.org/10.67214/pzrqwg35