CHANGES IN ASTHMA PREVALENCE, SYMPTOMS, AND ASSOCIATED RISK FACTORS AMONG ADOLESCENTS IN SKOPJE, 2016–2026

Authors

  • Mica Kimovska Hristova University Children's Hospital, Skopje Author

DOI:

https://doi.org/10.67214/9qjasx95

Keywords:

Ashtma in adolescents, trend of ashtma and ashtma-related symptom

Abstract

Background: Asthma is one of the most common chronic diseases in childhood, with considerable differences in prevalence and trends worldwide.

Objective: To assess asthma prevalence and changes over the 2016–2026 period among adolescents in Skopje, and to examine changes and associations with selected personal, family, behavioral, and environmental factors.

Materials and Methods: Data from two cross-sectional surveys conducted in Skopje in 2016 and 2026 were compared. Both surveys used the same standardized questionnaire on respiratory health and asthma. The analysis included 1,013 adolescents aged 12–15 years (690 in 2016 and 323 in 2026). Statistical analyses were performed using IBM SPSS Statistics version 25.0 and JASP version 0.98.1.

Results: The prevalence of doctor-diagnosed asthma was low (3.4%) and showed a slight increase, although the difference was not statistically significant. In contrast, several asthma-related symptoms increased significantly. Current wheeze increased from 5.5% to 9.9%, exercise-induced wheeze from 1.9% to 6.2%, and dry night cough from 9.6% to 20.7%. Measures of symptom severity also increased significantly. In the fully adjusted models, household dampness, maternal asthma, frequent fast-food consumption, paracetamol use, and truck traffic were positively associated with several asthma-related symptoms.

Conclusion: Asthma and asthma-related symptoms increased over the ten-year period, while underdiagnosis and inadequate treatment remained important concerns. The findings suggest a need for better education for healthcare professionals to improve asthma diagnosis and treatment, together with education of patients and parents on the regular and correct use of prescribed therapy.

Downloads

Download data is not yet available.

References

1. Global Initiative for Asthma. Global strategy for asthma management and prevention. 2026 update. Fontana (WI): Global Initiative for Asthma; 2026. Available on www.ginasthma.org.

2. Lai CKW, Beasley R, the ISAAC Phase Three Study Group, et al. Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2009; 64:476-483.

3. The global asthma report 2011. Paris, France: The International Union Against Tuberculosis and Lung Diseases; 2011. ISBN 978-2-914365-83-3.

4. Pearce N, Ait-Khaled N, the ISAAC Phase Three Study Group, et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007; 62:758-66.

5. Vlaski E, Stavrikj K, Kimovska M, et al. Divergent trends in the prevalence of asthma-like symptoms and asthma in a developing country: three repeated surveys between 2022 and 2016. Allergol Immunopathol (Madr) 2020;48(5):475-83.

6. Masoli M, Fabian D, Holt S, Beasley R for the Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee Report. Allergy 2004;59:469-78.11.

7. Akinbami LJ, Simon AE, Rossen LM. Changing trends in asthma prevalence among children. Pediatrics 2016;137(1):1-7. [https://doi: 10.1542/peds.2015-2354].

8. Sears MR. Trends in the prevalence of asthma. Chest 2014;145(2):219-25. [https://doi: 10.1378/chest.13-2059].

9. Lawson JA, Brozek G, Shpakou A, Fedortsiv O, Vlaski E, Beridze V, et al. An international comparison of asthma, wheeze, and breathing medication use among children. Respir Med. 2017;133:22–8.

10. Lung Health Study, University of Saskatchewan. Supported by a grant from the Saskatchewan Health Research Foundation.

11. ISAAC Phase Three Newsletter. December 2001, 9. http://isaac.auckland.ac.nz/news/media.html#

12. 12.Zhou W, Tang J. Prevalence and risk factors for childhood asthma: a systematic review and meta-analysis. BMC Pediatr. 2025;25(1):50. doi:10.1186/s12887-025-05409-x.

13. Brozek G, Lawson J, Szumilas D, Zejda J. Increasing prevalence of asthma, respiratory symptoms, and allergic diseases: four repeated surveys from 1993-2014. Respir Med 2015;109(8):982-90. [https:// doi: 10.1016/j.rmed.2015.05.010].

14. Maio S, Baldacci S, Carrozzi L, Pistelli F, Angino A, Simoni M, et al. Respiratory symptoms/diseases prevalence is still increasing: a 25-yr population study. Respir Med 2016;110:58-65. [https://doi: 10.1016/j.rmed.2015.11.006].

15. de Korte-de Boer D, Mommers M, Gielkens-Sijstermans CM, Creemers HM, Mujakovic S, Feron FJ, et al. Stabilizing prevalence trends of eczema, asthma and rhinoconjunctivitis in Dutch schoolchildren (2001-2010). Allergy 2015;70(12):1669-73. [https:// doi: 10.1111/all.12728].

16. Weber A, Herr C, Hendrowarsito L, Meyer N, Nennstiel-Ratzel U, von Mutius E, et al; GME Study Group. No further increase in the parent reported prevalence of allergies in Bavarian preschool children: Results from three cross-sectional studies. Int J Hyg Environ Health 2016;219(4-5):343-8. [https:// doi: 10.1016/j.ijheh.2016.02.001].

17. Engelkes M, Janssens HM, de Ridder MA, de Jongste JC, Sturkenboom MC, Verhamme KM. Time trends in the incidence, prevalence and age at diagnosis of asthma in children. Pediatr Allergy Immunol 2015;26(4):367-74. [https:// doi: 10.1111/pai.12376].

18. Bloom CI, Saglani S, Feary J, Jarvis D, Quint JK. Changing prevalence of current asthma and inhaled corticosteroid treatment in the UK: population-based cohort 2006-2016. Eur Respir J 2019;53:1802130 [https://doi.org/10.1183/13993003.02130-2018].

19. Vlaski E, Stavric K, Seckova L, Kimovska Hristova M, Isjanovska R. The self-reported density of truck traffic on residential streets and the impact on asthma, hay fever and eczema in young adolescents. Allergol Immunopathol (Madr). 2014;42(3):224–9.

20. Ellwood P, Asher MI, García-Marcos L, Williams H, Keil U, Robertson C, et al. Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three. Thorax. 2013;68(4):351–60.

21. Vlaski E, Stavric K, Isjanovska R, Seckova L, Kimovska M. Acetaminophen intake and risk of asthma, hay fever and eczema in early adolescence. Iran J Allergy Asthma Immunol. 2007;6(3):143–9.

22. Beasley RW, Clayton TO, Crane J, von Mutius E, Lai CKW, Montefort SR, et al. Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. Am J Respir Crit Care Med. 2011;183(2):171–8.

23. Singh M, Varukolu S, Chauhan A, et al. Paracetamol exposure and asthma: what does the evidence say? An overview of systematic reviews. Pediatr Pulmonol. 2021;56(10):3189–99.

Downloads

Published

30-09-2026

Data Availability Statement

Now the data are going to be available. only like an original article, in MJA.

How to Cite

CHANGES IN ASTHMA PREVALENCE, SYMPTOMS, AND ASSOCIATED RISK FACTORS AMONG ADOLESCENTS IN SKOPJE, 2016–2026. (2026). Macedonian Journal of Anaesthesia, 10(3), 55-67. https://doi.org/10.67214/9qjasx95